A temperature independent method of monitoring Chromatographic performance.

Accurate measurement of flow is a critical parameter in liquid chromatography systems where retention times and peak shape are often directly affected by flow rate. A new technical study demonstrates how, unlike tradition flowmeters and volumetric measuring devices, our Liquid Chromatography flowmeter offers laboratory professionals access to reliable, repeatable flow data throughout experiments and system validations, without the need to constantly adjust for temperature variations.

Precise Molecular Weight determination.

Our new LS Assistant is an easy-to-use accessory for Multiangle Light Scattering (MALS) instruments that delivers accurate and reliable specific refractive index (dn/dc) valves – a key parameter for Molecular Weight determination. Available in optimized models matched to the operating wavelength of your light scattering instrument – precisely determining the molecular weight of polymers, proteins and nanoparticles becomes routine.

June 12th 2025

Prep flowmeter improves production of lipid nanoparticles

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles for delivering various therapeutic drugs. With LNPs also finding increasing use as effective delivery agents in food and cosmetic applications there is considerable interest in improving the high-shear mixing, microfluidics, and thin-film hydration methods used to prepare them. These small-scale production methods often involve use of several fluidic pumps each delivering a necessary component to create the target LNP. In these preparative protocols, aliquots of reagents must be carefully controlled to maximize quality and yield. A growing number of labs are investing in TESTA Analytical Prep Flowmeters for LNP production as their high accuracy and fast response enables real time control of the flow of reagents from all involved pumps.

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Adaptive temperature control enhances RI detector performance.

Temperature control is crucial for refractive index detectors used in HPLC and GPC/SEC applications because the refractive index of a fluid is significantly affected by temperature changes. Even small temperature fluctuations can cause baseline instability and impact the accuracy of measurements. As part of the ongoing development of our Differential Refractive Index (DRI) detector technology we have developed a new self-adaptive (AI driven) temperature control feature that assures rock solid stability throughout the 30 °C to 80 °C temperature range. Benefiting from this powerful new algorithm our DRI detectors are able to reach a stable baseline in less than half the time of other RI detectors.